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As the NFL regular season barrels toward its second half, Week 12 arrives with plenty at stake — playoff hopes, division races, and momentum swings are all on the line. In this week’s predictions piece, we break down the matchups that matter most, spotlight potential surprises, and forecast winners (and maybe a few upsets). Whether you’re in it for sports betting, fantasy football, or just pure football passion, our picks this week reflect a mix of data-driven insight and gut-feel. Let’s huddle up and get ready for the action.
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Below is the updated Week 12 NFL schedule, including predictions based on current betting odds and expert analysis
. The Prediction column indicates the favored team based on point spreads and expert consensus, noting upsets are possible.Week 12 NFL Schedule and Predictions
| Matchup | Date | Time (ET) | Network | Point Spread | Prediction |
|---|---|---|---|---|---|
| Buffalo Bills @ Houston Texans | Thu, Nov 20 | 8:15 PM | Prime Video | BUF -4.5 | Bills Win; Texans likely to cover spread |
| NY Jets @ Baltimore Ravens | Sun, Nov 23 | 1:00 PM | CBS | BAL -14 | Ravens Win |
| Pittsburgh Steelers @ Chicago Bears | Sun, Nov 23 | 1:00 PM | CBS | CHI -3 | Bears Win (Experts pick Steelers +3) |
| New England Patriots @ Cincinnati Bengals | Sun, Nov 23 | 1:00 PM | CBS | NE -7 | Patriots Win |
| NY Giants @ Detroit Lions | Sun, Nov 23 | 1:00 PM | FOX | DET -10.5 | Lions Win |
| Minnesota Vikings @ Green Bay Packers | Sun, Nov 23 | 1:00 PM | FOX | GB -6.5 | Packers Win |
| Indianapolis Colts @ Kansas City Chiefs | Sun, Nov 23 | 1:00 PM | CBS | KC -3.5 | Chiefs Win (Experts favor Colts +3.5) |
| Seattle Seahawks @ Tennessee Titans | Sun, Nov 23 | 1:00 PM | FOX | SEA -13 | Seahawks Win |
| Jacksonville Jaguars @ Arizona Cardinals | Sun, Nov 23 | 4:05 PM | CBS | ARI -1.5 | Cardinals Win |
| Cleveland Browns @ Las Vegas Raiders | Sun, Nov 23 | 4:05 PM | FOX | LV -3 | Raiders Win |
| Philadelphia Eagles @ Dallas Cowboys | Sun, Nov 23 | 4:25 PM | FOX | PHI -3.5 | Eagles Win |
| Atlanta Falcons @ New Orleans Saints | Sun, Nov 23 | 4:25 PM | FOX | ATL -1.5 | Falcons Win |
| Tampa Bay Buccaneers @ LA Rams | Sun, Nov 23 | 8:20 PM | NBC | LAR -6.5 | Rams Win (Experts lean Bucs +6.5) |
| Carolina Panthers @ San Francisco 49ers | Mon, Nov 24 | 8:15 PM | ESPN | SF -6.5 | 49ers Win |
The "Prediction" column is based on the team favored by the majority of betting lines (point spread). An upset is possible in any game, and some experts favor the underdog against the spread (ATS) in several matchups, such as the Steelers and Colts.
Note: Betting odds and predictions are not guarantees and should be used for informational purposes only.
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